Induce irf8
WebIRF8 and IRF3 were shown to cooperatively regulate the rapid induction of IFN-β, suggesting cell type-specific functions of IRF8. Future studies will need to elucidate the … Web25 mrt. 2024 · In lung cancer cells, IRF8 negatively regulates Akt phosphorylation, inducing cellular senescence . In addition, inhibition of IRF8 expression levels has been found to …
Induce irf8
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Web7 mrt. 2015 · Irf8 −/− MDPs and cMoPs lack Klf4 expression, and IRF8 directly induces Klf4 probably via the IRF8-dependent distal enhancer. Introducing KLF4 into the Irf8 −/− … Web13 jan. 2024 · Ferroptosis has emerged as a cytotoxic T lymphocyte (CTL)-induced tumor cell death pathway. The regulation of tumor cell sensitivity to ferroptosis is incompletely …
WebIrf8 induction, but not its knockdown, decreased APL leukemogenic potential through driving monocytic maturation. Total cellular protein presence of the transcription factor … Web6 jan. 2024 · Mechanistically, we established that T-bet dependent ILC1-derived IFN-γ is critical for the induction of IRF8, an essential transcription factor for cDC1s. Failure to …
Web5 aug. 2013 · IFN-γand LPS slow down the intrinsic mobility of IRF8 inside the nucleus to enforce its chromatin interaction for the initiation of transcription . IFN-γinduces IRF-8 and IRF-8 drives to induction of IFN-β, IL-12p40, IL-12p35, and iNOS upon TLR stimulation, that is, M1 macrophage gene profile . Web6 apr. 2024 · 对BATF3而言，在相对于Irf8转录起始位点+32 kb的增强子中检测到DC-SCRIPT的结合，这对维持Irf8在cDC1中的表达至关重要。
Web10 mrt. 2011 · Knockdown of IRF8 in monocytes abrogated IFN-β transcription, whereas reintroduction of IRF8 into the IRF8 (-/-) 32Dcl3 murine myeloid cell line reinstated IFN-β …
Web25 nov. 2024 · Through RNA-seq method, I found that IRF8 depletion suppresses the expression of a group of genes involved in apoptosis and thus inhibits apoptosis … ball 32 oz mason jar dimensionsWebIRF8 and IRF3 were shown to cooperatively regulate the rapid induction of IFN-β, suggesting cell type-specific functions of IRF8. Future studies will need to elucidate the exact mechanisms by which IRF8 acts as an activator in one cell type, but as a repressor in another. Surprisingly, Steinhagen et al. [12] could not identify any sig- ball 3d run gameWebBecause IFN-γ can regulate the expression of several IRF8-binding partner proteins in sarcoma cell lines (19), we suspect that IFN-γ treatment may induce IRF8-binding … ball 2 jahreWeb10 aug. 2024 · In addition, modulating microglial development, IRF8 is also critical for microglia to adopt a pro-inflammatory gene signature in disease. For example, following … ball 32 oz canning jarsWebDisease relevance of Irf8 These results suggest a two-step model for chronic myeloid leukemia in BXH-2, in which inactivation of Icsbp1 predisposes to myeloproliferation and immunodeficiency [1]. ICSBP -/- and to a lesser degree also IRF2 -/- mice were highly susceptible to Listeria infection [2]. ball 1 cup jarWeb7 okt. 2011 · Interferon regulatory factor (IRF) 8 and IRF4 are structurally-related, hematopoietic cell-specific transcription factors that cooperatively regulate the differentiation of dendritic cells and B cells. Whilst in myeloid cells IRF8 is known to modulate growth and differentiation, the role of IRF4 is poorly understood. ball 64 oz canning jarsWeb13 jan. 2024 · tumor cells restored tumor cell sensitivity to intrinsic ferroptosis induction. Furthermore, IRF8.KO tumor cells grew significantly faster than WT tumor cells in … ball 8 oz canning jars