site stats

Irf8 genecards

WebMar 21, 2024 · IRF8 is a transcriptional activator of CD37 expression in diffuse large B-cell lymphoma. Global assessment of IRF8 as a novel cancer biomarker. Predicting the … WebIRF7 encodes interferon regulatory factor 7, a member of the interferon regulatory transcription factor (IRF) family. IRF7 has been shown to play a role in the transcriptional activation of virus-inducible cellular genes, including the type I interferon genes. In particular, IRF7 regulates many interferon-alpha genes. [5]

IRF8 regulates B-cell lineage specification, commitment, and ...

WebInterferon regulatory factor 8 also known as interferon consensus sequence-binding protein , is a protein that in humans is encoded by the IRF8 gene.[5][6][7] IRF8 is a transcription factor that plays critical roles in the regulation of lineage commitment and in myeloid cell maturation including the decision for a common myeloid progenitor to … In myeloid cells, IRF8 regulates the expression of Bax and Fas to regulate apoptosis. In chronic myelogenous leukemia (CML), IRF8 regulates acid ceramidase to mediate CML apoptosis. IRF8 is highly expressed in myeloid cells and was originally identified in as a critical lineage-specific transcription factor for myeloid cell differentiation, recent studies, however, have shown that IRF8 is also constitutively expressed in non-hematopoietic cancer cells, albeit at a lower leve… geek wear crates https://tammymenton.com

IRF8 single gene test - Blueprint Genetics

WebIRF8: Interferon Regulatory Factor 8: Protein Coding: Q02556: 52: GC16P085898: 104.12: 2: FOXF1: Forkhead Box F1: Protein Coding: Q12946: 48: GC16P086510: 13.39: 3: … WebRoseville, MI. $25. AM/FM radio vintage/antique 50’s . West Bloomfield, MI. $25. Vintage 1994 Joe’s Place 4 Plastics Cups & 1991 Hard Pack 5 Different Camel Characters Lighters … WebInterferon regulatory factor (IRF)-8 is a critical transcription factor involved in the pathogenesis of myeloid neoplasia. However, the underlying mechanisms in vivo are not well known. dc bar february 2023

Irf8 regulates the progression of myeloproliferative neoplasm-like ...

Category:IRF8 interferon regulatory factor 8 [ Homo sapiens …

Tags:Irf8 genecards

Irf8 genecards

Frontiers Mutation in Irf8 Gene (Irf8R294C) Impairs Type I IFN ...

WebMar 25, 2024 · IRF8 has also been found to be expressed and functional in non-hematopoietic cells such as epithelial cells [ 7, 8 ]. Studies of IRF8 mRNA levels in normal human colon and colorectal carcinoma (CRC) revealed that IRF8 is downregulated in tumor tissues as compared to non-malignant counterpart tissues. WebSep 20, 2016 · Interferon regulatory factor-8 (IRF8) has been proposed to be essential for development of monocytes, plasmacytoid dendritic cells (pDCs) and type 1 conventional …

Irf8 genecards

Did you know?

WebNov 17, 2024 · IRF8 R294C mice were crossed with C57BL/6 wild-type female for at least three generations to eliminate the vertical transmission of Murine Leukemia Virus (MuLV). Progenies were crossed to generate the mice carrying homozygous alleles for the mutation, and all the mice were used at the age of 8–12 weeks. WebSymbol Description Category UniProt ID GIFtS GC id Score; 301: PPARGC1A: PPARG Coactivator 1 Alpha: Protein Coding: Q9UBK2: 53: GC04M023755: 0.43: 302: PTPRO: Protein Tyrosine Phosphatase Receptor Type O

WebAug 8, 2024 · IRF8 is a key regulator of innate immunity receptor signaling and plays diverse functions in the development of hematopoietic cells. The effects of IRF8 on hematopoietic stem cells (HSCs) are still unknown. Here, it is demonstrated that IRF8 deficiency results in a decreased number of long-term HSCs (LT-HSCs) in mice. WebProtein Interferon regulatory factor 8 Gene Irf8 Status UniProtKB reviewed (Swiss-Prot) Organism Mus musculus (Mouse) Amino acids 424 Protein existence Evidence at protein level Annotation score 5/5 Entry Feature viewer Publications External links History BLAST Download Add a publication Entry feedback Function

WebMar 21, 2024 · IRF8 (Interferon Regulatory Factor 8) is a Protein Coding gene. Diseases associated with IRF8 include Immunodeficiency 32A and Immunodeficiency 32B. Among …

WebNov 15, 2008 · IRF8 is known to bind to any of 4 distinct target sequences in genes subject to transcriptional activation or repression by IRF8. 29 Studies of the regulatory sequences of Sfpi1, which encodes PU.1, identified 2 possible IRF8 target sites.

WebAug 24, 2024 · IRF8 was originally identified as an essentialfactor for myeloid cell lineage commitment and differentiation. Deletion of Irf8 leads to massive accumulation of CD11b … dc bar newsWebInterferon regulatory factor 8 (Irf8), also known as interferon consensus sequence-binding protein, is a component of the Irf transcription factor family. Irf8 is differentially expressed … geek window cleaning houstonWebIFN regulatory factor (IRF) 8 is a transcription factor that has a key role in the cellular response to IFN-γ and is pivotal in myeloid cell differentiation. Whether IRF8 plays a role in the development and function of microglia, the tissue-resident myeloid cells of … dc bar publicationsWebJan 14, 2024 · MalaCards Gene Search: IRF8 Diseases sorted by gene-association score: immunodeficiency 32a, mycobacteriosis, autosomal dominant* (1650), immunodeficiency … geek wear t shirtsWebInterferon regulatory factor 8 (IRF8) also known as interferon consensus sequence-binding protein (ICSBP), is a protein that in humans is encoded by the IRF8 gene. [5] [6] [7] IRF8 is … dc bar registrationWebIRF8 expression based on TCGA samples Transcript per million Expression of IRF8 in LUAD based on Sample types Normal (n=59) Primary tumor (n=515) 0 10 20 30 40 50 60 LUAD : Lung adenocarcinoma Pan-cancer view Methylation Survival Protein Exp (CPTAC) Correlated genes DepMap External Links geekwire cell phoneWebAug 24, 2024 · IRF8 was originally identified as an essentialfactor for myeloid cell lineage commitment and differentiation. Deletion of Irf8 leads to massive accumulation of CD11b + Gr1 + immature myeloid cells (IMCs), particularly the CD11b + Ly6C hi/+ Ly6G - polymorphonuclear myeloid-derived suppressor cell-like cells (PMN-MDSCs). dc bar notice