WebApr 29, 2024 · Idiopathic pulmonary fibrosis (IPF) is a chronic and progressive lung disease of unknown etiology with limited treatment options. It is characterized by repetitive injury … Taken together, our in vivo results strongly identify 15-PGDH as a therapeutic target in murine bleomycin-induced PF. To determine if therapeutic targets exist in human lung tissue, we characterized 15-PGDH expression in human lung sections incidentally removed on autopsy. 15-PGDH was expressed in 6 of … See more (+)SW033291 is known to increase systemic PGE2 levels and enhance tissue regeneration26. To determine if 15-PGDH may be targetable in the … See more In mice, administration of bleomycin results in lung injury that mimics key aspects of human IPF28, with an initial inflammatory phase followed by a subsequent … See more The above results demonstrate that PGDHi mitigates acute inflammatory responses to bleomycin lung injury. To test whether PGDHi additionally protects … See more Known cellular drivers of PF pathogenesis include alveolar epithelial cells and fibroblasts1. To identify the cell types that PGDHi may act directly on during PF, we … See more
Pulmonary Fibrosis American Lung Association
WebJul 15, 2024 · Long-term PGDHi was well-tolerated, reduced the severity of pulmonary fibrotic lesions and extracellular matrix remodeling, and improved pulmonary function in bleomycin-treated mice. Moreover, PGDHi attenuated both acute inflammation and weight loss, and decreased mortality. WebApr 18, 2024 · Join the Greater Hartford Pulmonary Fibrosis support group on Tuesday, February 21, 2024 for a virtual meeting at 1:00 pm Eastern Time. PFF Guest Registry Topic … filterdirectory
Frontiers Metabolic reprogramming of pulmonary fibrosis
WebUsing a newly developed small molecule inhibitor of PHGDH (NCT-503), we tested whether pharmacologic inhibition of PHGDH could inhibit fibrogenesis both in vitro and in vivo. … WebJan 19, 2024 · Idiopathic pulmonary fibrosis (IPF) is a progressive, lethal fibrotic lung disease that occurs primarily in middle-aged and elderly adults. It is a major cause of morbidity and mortality. With an increase in life expectancy, the economic burden of IPF is expected to continuously rise in the near future. Although the exact pathophysiological … WebMar 6, 2024 · Pulmonary fibrosis is a chronic, progressive disease, meaning it worsens over time. Learning more about the disease can help you and your family cope. Attending … grown ups fart in the diapers